Kalpana was born on July 1st, 1961 to Banarasi Lal Chawla and Sanyogita Devi in Karnal, India. She completed her earlier schooling at Tagore Baal Niketan Senior Secondary School, Karnal and completed her Bachelor of Engineering degree in Aeronautical Engineering at Punjab Engineering College at Chandigarh in 1982. She moved to the United States in 1982 where she obtained a Master of Science degree in aerospace engineering from the University of Texas at Arlington in 1984. Determined to become an astronaut even in the face of the Challenger disaster, Chawla went on to earn a second Masters in 1986 and a PhD in aerospace engineering in 1988 from the University of Colorado at Boulder.