Autoimmunity
III. Systemic (Non-Organ specific) Autoimmune diseases
This group includes conditions characterized by immune response against a variety of self-antigens and damage to several organs and tissue systems.
(i) Systemic lupus erythematosus
This is a chronic, multisystem disease with remissions and exacertations, terminating fatally.
(ii) Rheumatoid Arthritis
This is a systemic poly arthritis with muscle wasting and subcutaneous nodules, commonly associated with serositis, myocarditis, vasculitis and other disseminated lesions. It is found more commonly in women.
(iii) Polyartheritis
This is a necrotizing angiitis involving medium sized arteries, ending fatally due to coronary thrombosis, cerebral hemorrhage or gastrointestinal bleeding.
(iv) Sjogren syndrome
This is a triad of conjuctivities sicca, dryness of the mouth, with or without salivary gland enlargement, and rheumatoid arthritis.