Protein chip/arrays are solid-phase ligand binding assay systems using immobilised proteins on surfaces which include glass, membranes, microtiter wells, mass spectrometer plates, and beads or other particles. The assays are highly multiplexed and are often miniaturised (microarrays, protein chips).

On one array plate several hundred proteins are spotted (immobilized).

Thus, in a single experiment data about several hundred proteins is generated.

The process is rapid and automatable.

Recent advances in detection techniques provide very high sensitivity.

The data handling and data comparison analysis requires sophisticated software.